Miguel Díaz-Canel spoke to crowds in Havana the US is attempting to break down Cuba’s political system.
He said the US seeks complete control across the nation.
Díaz-Canel branded American policies a case of political genocide during July 26 events.
He stressed this is a danger to the country's sovereignty.
Raúl Castro was absent from the biggest rally.
Tensions are elevated due to sanctions and US political pressure.